A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

Dennis Wolf; Nathaly Anto-Michel; Hermann Blankenbach; Ansgar Wiedemann; Konrad Buscher; Jan David Hohmann; Bock Lim; Marina Bäuml; Alex Marki; Maximilian Mauler; Daniel Duerschmied; Zhichao Fan; Holger Winkels; Daniel Sidler; Philipp Diehl; Dirk M. Zajonc; Ingo Hilgendorf; Peter Stachon; Timoteo Marchini; Florian Willecke; Maximilian Schell; Björn Sommer; Constantin Von Zur Muhlen; Jochen Reinöhl; Teresa Gerhardt; Edward F. Plow; Valentin Yakubenko; Peter Libby; Christoph Bode; Klaus Ley; Karlheinz Peter; Andreas Zirlik

doi:10.1038/s41467-018-02896-8

A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

Dennis Wolf
, Nathaly Anto-Michel
, Hermann Blankenbach
, Ansgar Wiedemann
, Konrad Buscher
, Jan David Hohmann
, Bock Lim
, Marina Bäuml
, Alex Marki
, Maximilian Mauler
, Daniel Duerschmied
, Zhichao Fan
, Holger Winkels
, Daniel Sidler
, Philipp Diehl
, Dirk M. Zajonc
, Ingo Hilgendorf
, Peter Stachon
, Timoteo Marchini
, Florian Willecke

Maximilian Schell, Björn Sommer, Constantin Von Zur Muhlen, Jochen Reinöhl, Teresa Gerhardt, Edward F. Plow, Valentin Yakubenko, Peter Libby, Christoph Bode, Klaus Ley, Karlheinz Peter, Andreas Zirlik

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	525
Journal	Nature Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-02896-8
State	Published - Dec 1 2018

ASJC Scopus Subject Areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

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Wolf, D., Anto-Michel, N., Blankenbach, H., Wiedemann, A., Buscher, K., Hohmann, J. D., Lim, B., Bäuml, M., Marki, A., Mauler, M., Duerschmied, D., Fan, Z., Winkels, H., Sidler, D., Diehl, P., Zajonc, D. M., Hilgendorf, I., Stachon, P., Marchini, T., ... Zirlik, A. (2018). A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Nature Communications, 9(1), Article 525. https://doi.org/10.1038/s41467-018-02896-8

Wolf, D, Anto-Michel, N, Blankenbach, H, Wiedemann, A, Buscher, K, Hohmann, JD, Lim, B, Bäuml, M, Marki, A, Mauler, M, Duerschmied, D, Fan, Z, Winkels, H, Sidler, D, Diehl, P, Zajonc, DM, Hilgendorf, I, Stachon, P, Marchini, T, Willecke, F, Schell, M, Sommer, B, Von Zur Muhlen, C, Reinöhl, J, Gerhardt, T, Plow, EF, Yakubenko, V, Libby, P, Bode, C, Ley, K, Peter, K & Zirlik, A 2018, 'A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense', Nature Communications, vol. 9, no. 1, 525. https://doi.org/10.1038/s41467-018-02896-8

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author = "Dennis Wolf and Nathaly Anto-Michel and Hermann Blankenbach and Ansgar Wiedemann and Konrad Buscher and Hohmann, \{Jan David\} and Bock Lim and Marina B{\"a}uml and Alex Marki and Maximilian Mauler and Daniel Duerschmied and Zhichao Fan and Holger Winkels and Daniel Sidler and Philipp Diehl and Zajonc, \{Dirk M.\} and Ingo Hilgendorf and Peter Stachon and Timoteo Marchini and Florian Willecke and Maximilian Schell and Bj{\"o}rn Sommer and \{Von Zur Muhlen\}, Constantin and Jochen Rein{\"o}hl and Teresa Gerhardt and Plow, \{Edward F.\} and Valentin Yakubenko and Peter Libby and Christoph Bode and Klaus Ley and Karlheinz Peter and Andreas Zirlik",

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AU - Wolf, Dennis

AU - Anto-Michel, Nathaly

AU - Blankenbach, Hermann

AU - Wiedemann, Ansgar

AU - Buscher, Konrad

AU - Hohmann, Jan David

AU - Lim, Bock

AU - Bäuml, Marina

AU - Marki, Alex

AU - Mauler, Maximilian

AU - Duerschmied, Daniel

AU - Fan, Zhichao

AU - Winkels, Holger

AU - Sidler, Daniel

AU - Diehl, Philipp

AU - Zajonc, Dirk M.

AU - Hilgendorf, Ingo

AU - Stachon, Peter

AU - Marchini, Timoteo

AU - Willecke, Florian

AU - Schell, Maximilian

AU - Sommer, Björn

AU - Von Zur Muhlen, Constantin

AU - Reinöhl, Jochen

AU - Gerhardt, Teresa

AU - Plow, Edward F.

AU - Yakubenko, Valentin

AU - Libby, Peter

AU - Bode, Christoph

AU - Ley, Klaus

AU - Peter, Karlheinz

AU - Zirlik, Andreas

PY - 2018/12/1

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SN - 2041-1723

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JO - Nature Communications

JF - Nature Communications

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ER -

A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

ASJC Scopus Subject Areas

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