TY - JOUR
T1 - A Longitudinal Study of p300 Brain-Computer Interface and Progression of Amyotrophic Lateral Sclerosis
AU - Gates, Nathan A.
AU - Hauser, Christopher K.
AU - Sellers, Eric W.
PY - 2011/7/19
Y1 - 2011/7/19
N2 - BCI can provide communication for people locked in by amyotrophic lateral sclerosis (ALS). Empirical examination of how disease progression affects brain-computer interface (BCI) performance has not been investigated. This pilot study uses a longitudinal design to investigate changes in P300-BCI use as ALS disability increases. We aimed to (a) examine the relationship between BCI accuracy and the ALS/Functional Rating Scale and (b) examine changes in the event-related potential (ERP) components across time. Eight subjects have been enrolled in the study. BCI accuracy was measured and ERP components were assessed by a principal component analysis (PCA). Two subjects have been followed for an average of nine-months, and BCI accuracy is 99.6%. While many research obstacles remain, these preliminary data help elucidate the relationship between BCI performance and disease progression.
AB - BCI can provide communication for people locked in by amyotrophic lateral sclerosis (ALS). Empirical examination of how disease progression affects brain-computer interface (BCI) performance has not been investigated. This pilot study uses a longitudinal design to investigate changes in P300-BCI use as ALS disability increases. We aimed to (a) examine the relationship between BCI accuracy and the ALS/Functional Rating Scale and (b) examine changes in the event-related potential (ERP) components across time. Eight subjects have been enrolled in the study. BCI accuracy was measured and ERP components were assessed by a principal component analysis (PCA). Two subjects have been followed for an average of nine-months, and BCI accuracy is 99.6%. While many research obstacles remain, these preliminary data help elucidate the relationship between BCI performance and disease progression.
KW - P300 event-related potential
KW - amyotrophic lateral sclerosis
KW - assistive communication
KW - brain-computer interface
KW - electroencephalogram
UR - https://dc.etsu.edu/etsu-works/16429
UR - https://doi.org/10.1007/978-3-642-21852-1_54
U2 - 10.1007/978-3-642-21852-1_54
DO - 10.1007/978-3-642-21852-1_54
M3 - Article
VL - 6780 LNAI
JO - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
JF - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
ER -