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Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5

  • Fukang Yang
  • , Lawrence B. Snyder
  • , Anand Balakrishnan
  • , Jeffrey M. Brown
  • , Digavalli V. Sivarao
  • , Amy Easton
  • , Alda Fernandes
  • , Michael Gulianello
  • , Umesh M. Hanumegowda
  • , Hong Huang
  • , Yanling Huang
  • , Kelli M. Jones
  • , Yu Wen Li
  • , Michele Matchett
  • , Gail Mattson
  • , Regina Miller
  • , Kenneth S. Santone
  • , Arun Senapati
  • , Eric E. Shields
  • , Frank J. Simutis
  • Ryan Westphal, Valerie J. Whiterock, Joanne J. Bronson, John E. MacOr, Andrew P. Degnan
  • Bristol-Myers Squibb

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)289-293
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume7
Issue number3
DOIs
StatePublished - Mar 10 2016

ASJC Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • cognition
  • mGluR5
  • neurotoxicity
  • positive allosteric modulator
  • schizophrenia

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