Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain

Guanglin Luo; Ling Chen; Amy Easton; Amy Newton; Clotilde Bourin; Eric Shields; Kathy Mosure; Matthew G. Soars; Ronald J. Knox; Michele Matchett; Rick L. Pieschl; Debra J. Post-Munson; Shuya Wang; James Herrington; John Graef; Kimberly Newberry; Digavalli V. Sivarao; Arun Senapati; Linda J. Bristow; Nicholas A. Meanwell; Lorin A. Thompson; Carolyn Dzierba

doi:10.1021/acs.jmedchem.8b01550

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na_V1.7 Inhibitors for the Treatment of Pain

Guanglin Luo
, Ling Chen
, Amy Easton
, Amy Newton
, Clotilde Bourin
, Eric Shields
, Kathy Mosure
, Matthew G. Soars
, Ronald J. Knox
, Michele Matchett
, Rick L. Pieschl
, Debra J. Post-Munson
, Shuya Wang
, James Herrington
, John Graef
, Kimberly Newberry
, Digavalli V. Sivarao
, Arun Senapati
, Linda J. Bristow
, Nicholas A. Meanwell

Lorin A. Thompson, Carolyn Dzierba

Department of Pharmaceutical Sciences

Bristol-Myers Squibb Research and Development

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	831-856
Number of pages	26
Journal	Journal of Medicinal Chemistry
Volume	62
Issue number	2
DOIs	https://doi.org/10.1021/acs.jmedchem.8b01550
State	Published - Jan 24 2019

ASJC Scopus Subject Areas

Molecular Medicine
Drug Discovery

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10.1021/acs.jmedchem.8b01550

Cite this

Luo, G., Chen, L., Easton, A., Newton, A., Bourin, C., Shields, E., Mosure, K., Soars, M. G., Knox, R. J., Matchett, M., Pieschl, R. L., Post-Munson, D. J., Wang, S., Herrington, J., Graef, J., Newberry, K., Sivarao, D. V., Senapati, A., Bristow, L. J., ... Dzierba, C. (2019). Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na_V1.7 Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry, 62(2), 831-856. https://doi.org/10.1021/acs.jmedchem.8b01550

Luo, G, Chen, L, Easton, A, Newton, A, Bourin, C, Shields, E, Mosure, K, Soars, MG, Knox, RJ, Matchett, M, Pieschl, RL, Post-Munson, DJ, Wang, S, Herrington, J, Graef, J, Newberry, K, Sivarao, DV, Senapati, A, Bristow, LJ, Meanwell, NA, Thompson, LA & Dzierba, C 2019, 'Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na_V1.7 Inhibitors for the Treatment of Pain', Journal of Medicinal Chemistry, vol. 62, no. 2, pp. 831-856. https://doi.org/10.1021/acs.jmedchem.8b01550

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title = "Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain",

author = "Guanglin Luo and Ling Chen and Amy Easton and Amy Newton and Clotilde Bourin and Eric Shields and Kathy Mosure and Soars, \{Matthew G.\} and Knox, \{Ronald J.\} and Michele Matchett and Pieschl, \{Rick L.\} and Post-Munson, \{Debra J.\} and Shuya Wang and James Herrington and John Graef and Kimberly Newberry and Sivarao, \{Digavalli V.\} and Arun Senapati and Bristow, \{Linda J.\} and Meanwell, \{Nicholas A.\} and Thompson, \{Lorin A.\} and Carolyn Dzierba",

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doi = "10.1021/acs.jmedchem.8b01550",

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T1 - Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain

AU - Luo, Guanglin

AU - Chen, Ling

AU - Easton, Amy

AU - Newton, Amy

AU - Bourin, Clotilde

AU - Shields, Eric

AU - Mosure, Kathy

AU - Soars, Matthew G.

AU - Knox, Ronald J.

AU - Matchett, Michele

AU - Pieschl, Rick L.

AU - Post-Munson, Debra J.

AU - Wang, Shuya

AU - Herrington, James

AU - Graef, John

AU - Newberry, Kimberly

AU - Sivarao, Digavalli V.

AU - Senapati, Arun

AU - Bristow, Linda J.

AU - Meanwell, Nicholas A.

AU - Thompson, Lorin A.

AU - Dzierba, Carolyn

PY - 2019/1/24

Y1 - 2019/1/24

UR - https://www.scopus.com/pages/publications/85060034710

UR - https://www.scopus.com/pages/publications/85060034710#tab=citedBy

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DO - 10.1021/acs.jmedchem.8b01550

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AN - SCOPUS:85060034710

SN - 0022-2623

VL - 62

SP - 831

EP - 856

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 2

ER -

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain

ASJC Scopus Subject Areas

Access to Document

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Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na_V1.7 Inhibitors for the Treatment of Pain