Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception

Digavalli V. Sivarao; Kimberly Newberry; Shaun Langdon; Alicia V. Lee; Piyasena Hewawasam; Mary Jane Plym; Laura Signor; Robert Myers; Nicholas J. Lodge

doi:10.1124/jpet.104.079285

Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca²⁺-activated K⁺ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception

Digavalli V. Sivarao
, Kimberly Newberry
, Shaun Langdon
, Alicia V. Lee
, Piyasena Hewawasam
, Mary Jane Plym
, Laura Signor
, Robert Myers
, Nicholas J. Lodge

Department of Pharmaceutical Sciences

Bristol-Myers Squibb

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	840-847
Number of pages	8
Journal	Journal of Pharmacology and Experimental Therapeutics
Volume	313
Issue number	2
DOIs	https://doi.org/10.1124/jpet.104.079285
State	Published - May 2005

ASJC Scopus Subject Areas

Molecular Medicine
Pharmacology

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10.1124/jpet.104.079285

Cite this

Sivarao, D. V., Newberry, K., Langdon, S., Lee, A. V., Hewawasam, P., Plym, M. J., Signor, L., Myers, R., & Lodge, N. J. (2005). Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca²⁺-activated K⁺ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. Journal of Pharmacology and Experimental Therapeutics, 313(2), 840-847. https://doi.org/10.1124/jpet.104.079285

Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca²⁺-activated K⁺ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. / Sivarao, Digavalli V.; Newberry, Kimberly; Langdon, Shaun et al.
In: Journal of Pharmacology and Experimental Therapeutics, Vol. 313, No. 2, 05.2005, p. 840-847.

Research output: Contribution to journal › Article › peer-review

Sivarao, DV, Newberry, K, Langdon, S, Lee, AV, Hewawasam, P, Plym, MJ, Signor, L, Myers, R & Lodge, NJ 2005, 'Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca²⁺-activated K⁺ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception', Journal of Pharmacology and Experimental Therapeutics, vol. 313, no. 2, pp. 840-847. https://doi.org/10.1124/jpet.104.079285

Sivarao DV, Newberry K, Langdon S, Lee AV, Hewawasam P, Plym MJ et al. Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca²⁺-activated K⁺ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. Journal of Pharmacology and Experimental Therapeutics. 2005 May;313(2):840-847. doi: 10.1124/jpet.104.079285

Sivarao, Digavalli V. ; Newberry, Kimberly ; Langdon, Shaun et al. / Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca²⁺-activated K⁺ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. In: Journal of Pharmacology and Experimental Therapeutics. 2005 ; Vol. 313, No. 2. pp. 840-847.

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Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception

ASJC Scopus Subject Areas

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Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca²⁺-activated K⁺ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception