Enhancement of Sprouting and Putative Regeneration of Central Noradrenergic Fibers by Morphine

Craig T. Harston; Anne Morrow; Richard M. Kostrzewa

doi:10.1016/S0361-9230(80)80012-8

Enhancement of Sprouting and Putative Regeneration of Central Noradrenergic Fibers by Morphine

Craig T. Harston
, Anne Morrow
, Richard M. Kostrzewa

Department of Biomedical Sciences

East Tennessee State University

Research output: Contribution to journal › Article › peer-review

Abstract

Treatment of newborn rats with 6-hydroxydopa (6-OHDOPA, 60 μg/g IP) increased the levels of norepinephrine in the adult cerebellum and hindbrain. Concurrent treatment with morphine sulfate (20 μg/g IP) potentiated the response to 6-OHDOPA in the cerebellum and pons-medulla. In addition, increased noradrenergic neurite density in 4 week cerebellar cortex (as observed with histofluorescent staining by glyoxylic acid) suggests that neonatal morphine increased the sprouting of noradrenergic neurons in the 6-OHDOPA treated rats.

Original language	American English
Journal	Brain Research Bulletin
Volume	5
DOIs	https://doi.org/10.1016/S0361-9230(80)80012-8
State	Published - Jan 1 1980

Keywords

6-hydroxydopa
hindbrain and cerebellum
morphine
neural regenerative sprouting
noradrenergic system

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https://doi.org/10.1016/S0361-9230(80)80012-8

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title = "Enhancement of Sprouting and Putative Regeneration of Central Noradrenergic Fibers by Morphine",

abstract = " Treatment of newborn rats with 6-hydroxydopa (6-OHDOPA, 60 μg/g IP) increased the levels of norepinephrine in the adult cerebellum and hindbrain. Concurrent treatment with morphine sulfate (20 μg/g IP) potentiated the response to 6-OHDOPA in the cerebellum and pons-medulla. In addition, increased noradrenergic neurite density in 4 week cerebellar cortex (as observed with histofluorescent staining by glyoxylic acid) suggests that neonatal morphine increased the sprouting of noradrenergic neurons in the 6-OHDOPA treated rats.",

keywords = "6-hydroxydopa, hindbrain and cerebellum, morphine, neural regenerative sprouting, noradrenergic system",

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AU - Morrow, Anne

AU - Kostrzewa, Richard M.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - Treatment of newborn rats with 6-hydroxydopa (6-OHDOPA, 60 μg/g IP) increased the levels of norepinephrine in the adult cerebellum and hindbrain. Concurrent treatment with morphine sulfate (20 μg/g IP) potentiated the response to 6-OHDOPA in the cerebellum and pons-medulla. In addition, increased noradrenergic neurite density in 4 week cerebellar cortex (as observed with histofluorescent staining by glyoxylic acid) suggests that neonatal morphine increased the sprouting of noradrenergic neurons in the 6-OHDOPA treated rats.

AB - Treatment of newborn rats with 6-hydroxydopa (6-OHDOPA, 60 μg/g IP) increased the levels of norepinephrine in the adult cerebellum and hindbrain. Concurrent treatment with morphine sulfate (20 μg/g IP) potentiated the response to 6-OHDOPA in the cerebellum and pons-medulla. In addition, increased noradrenergic neurite density in 4 week cerebellar cortex (as observed with histofluorescent staining by glyoxylic acid) suggests that neonatal morphine increased the sprouting of noradrenergic neurons in the 6-OHDOPA treated rats.

KW - 6-hydroxydopa

KW - hindbrain and cerebellum

KW - morphine

KW - neural regenerative sprouting

KW - noradrenergic system

UR - https://dc.etsu.edu/etsu-works/13206

UR - https://doi.org/10.1016/S0361-9230(80)80012-8

U2 - 10.1016/S0361-9230(80)80012-8

DO - 10.1016/S0361-9230(80)80012-8

M3 - Article

VL - 5

JO - Brain Research Bulletin

JF - Brain Research Bulletin

ER -

Enhancement of Sprouting and Putative Regeneration of Central Noradrenergic Fibers by Morphine

Abstract

Keywords

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