Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "doorstop" for NADPH Entry

Ilaria Silvestri; Haining Lyu; Francesca Fata; Giovanna Boumis; Adriana E. Miele; Matteo Ardini; Rodolfo Ippoliti; Andrea Bellelli; Ajit Jadhav; Wendy A. Lea; Anton Simeonov; Qing Cheng; Elias S.J. Arnér; Gregory R.J. Thatcher; Pavel A. Petukhov; David L. Williams; Francesco Angelucci

doi:10.1021/acschembio.8b00349

Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "doorstop" for NADPH Entry

Ilaria Silvestri
, Haining Lyu
, Francesca Fata
, Giovanna Boumis
, Adriana E. Miele
, Matteo Ardini
, Rodolfo Ippoliti
, Andrea Bellelli
, Ajit Jadhav
, Wendy A. Lea
, Anton Simeonov
, Qing Cheng
, Elias S.J. Arnér
, Gregory R.J. Thatcher
, Pavel A. Petukhov
, David L. Williams
, Francesco Angelucci

Department of Surgery

Università dell'Aquila
Rush University Medical Center
Universita 'La Sapienza'
Université de Lyon
National Center for Advancing Translational Sciences (NCATS)
Karolinska Institutet
University of Illinois at Chicago

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	2190-2202
Number of pages	13
Journal	ACS Chemical Biology
Volume	13
Issue number	8
DOIs	https://doi.org/10.1021/acschembio.8b00349
State	Published - Aug 17 2018

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine

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10.1021/acschembio.8b00349

Cite this

Silvestri, I., Lyu, H., Fata, F., Boumis, G., Miele, A. E., Ardini, M., Ippoliti, R., Bellelli, A., Jadhav, A., Lea, W. A., Simeonov, A., Cheng, Q., Arnér, E. S. J., Thatcher, G. R. J., Petukhov, P. A., Williams, D. L., & Angelucci, F. (2018). Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "doorstop" for NADPH Entry. ACS Chemical Biology, 13(8), 2190-2202. https://doi.org/10.1021/acschembio.8b00349

Silvestri, I, Lyu, H, Fata, F, Boumis, G, Miele, AE, Ardini, M, Ippoliti, R, Bellelli, A, Jadhav, A, Lea, WA, Simeonov, A, Cheng, Q, Arnér, ESJ, Thatcher, GRJ, Petukhov, PA, Williams, DL & Angelucci, F 2018, 'Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "doorstop" for NADPH Entry', ACS Chemical Biology, vol. 13, no. 8, pp. 2190-2202. https://doi.org/10.1021/acschembio.8b00349

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title = "Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as {"}doorstop{"} for NADPH Entry",

author = "Ilaria Silvestri and Haining Lyu and Francesca Fata and Giovanna Boumis and Miele, \{Adriana E.\} and Matteo Ardini and Rodolfo Ippoliti and Andrea Bellelli and Ajit Jadhav and Lea, \{Wendy A.\} and Anton Simeonov and Qing Cheng and Arn{\'e}r, \{Elias S.J.\} and Thatcher, \{Gregory R.J.\} and Petukhov, \{Pavel A.\} and Williams, \{David L.\} and Francesco Angelucci",

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doi = "10.1021/acschembio.8b00349",

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AU - Silvestri, Ilaria

AU - Lyu, Haining

AU - Fata, Francesca

AU - Boumis, Giovanna

AU - Miele, Adriana E.

AU - Ardini, Matteo

AU - Ippoliti, Rodolfo

AU - Bellelli, Andrea

AU - Jadhav, Ajit

AU - Lea, Wendy A.

AU - Simeonov, Anton

AU - Cheng, Qing

AU - Arnér, Elias S.J.

AU - Thatcher, Gregory R.J.

AU - Petukhov, Pavel A.

AU - Williams, David L.

AU - Angelucci, Francesco

PY - 2018/8/17

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Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "doorstop" for NADPH Entry

ASJC Scopus Subject Areas

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