Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Rob J.W. Arts; Boris Novakovic; Rob ter Horst; Agostinho Carvalho; Siroon Bekkering; Ekta Lachmandas; Fernando Rodrigues; Ricardo Silvestre; Shih Chin Cheng; Shuang Yin Wang; Ehsan Habibi; Luís G. Gonçalves; Inês Mesquita; Cristina Cunha; Arjan van Laarhoven; Frank L. van de Veerdonk; David L. Williams; Jos W.M. van der Meer; Colin Logie; Luke A. O'Neill; Charles A. Dinarello; Niels P. Riksen; Reinout van Crevel; Clary Clish; Richard A. Notebaart; Leo A.B. Joosten; Hendrik G. Stunnenberg; Ramnik J. Xavier; Mihai G. Netea

doi:10.1016/j.cmet.2016.10.008

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Rob J.W. Arts
, Boris Novakovic
, Rob ter Horst
, Agostinho Carvalho
, Siroon Bekkering
, Ekta Lachmandas
, Fernando Rodrigues
, Ricardo Silvestre
, Shih Chin Cheng
, Shuang Yin Wang
, Ehsan Habibi
, Luís G. Gonçalves
, Inês Mesquita
, Cristina Cunha
, Arjan van Laarhoven
, Frank L. van de Veerdonk
, David L. Williams
, Jos W.M. van der Meer
, Colin Logie
, Luke A. O'Neill

Charles A. Dinarello, Niels P. Riksen, Reinout van Crevel, Clary Clish, Richard A. Notebaart, Leo A.B. Joosten, Hendrik G. Stunnenberg, Ramnik J. Xavier, Mihai G. Netea

Department of Surgery

Radboud University Medical Center
Radboud University Nijmegen
University of Minho
ICVS/3B's - PT Government Associate Laboratory
National Tsing Hua University
Universidade Nova de Lisboa
Trinity College Dublin
University of Colorado School of Medicine
Broad Institute
Massachusetts General Hospital

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	807-819
Number of pages	13
Journal	Cell Metabolism
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2016.10.008
State	Published - Dec 13 2016

ASJC Scopus Subject Areas

Physiology
Molecular Biology
Cell Biology

Keywords

cholesterol metabolism
epigenetics
glutamine metabolism
glycolysis
trained immunity

Access to Document

10.1016/j.cmet.2016.10.008

Cite this

Arts, R. J. W., Novakovic, B., ter Horst, R., Carvalho, A., Bekkering, S., Lachmandas, E., Rodrigues, F., Silvestre, R., Cheng, S. C., Wang, S. Y., Habibi, E., Gonçalves, L. G., Mesquita, I., Cunha, C., van Laarhoven, A., van de Veerdonk, F. L., Williams, D. L., van der Meer, J. W. M., Logie, C., ... Netea, M. G. (2016). Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity. Cell Metabolism, 24(6), 807-819. https://doi.org/10.1016/j.cmet.2016.10.008

Arts, RJW, Novakovic, B, ter Horst, R, Carvalho, A, Bekkering, S, Lachmandas, E, Rodrigues, F, Silvestre, R, Cheng, SC, Wang, SY, Habibi, E, Gonçalves, LG, Mesquita, I, Cunha, C, van Laarhoven, A, van de Veerdonk, FL, Williams, DL, van der Meer, JWM, Logie, C, O'Neill, LA, Dinarello, CA, Riksen, NP, van Crevel, R, Clish, C, Notebaart, RA, Joosten, LAB, Stunnenberg, HG, Xavier, RJ & Netea, MG 2016, 'Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity', Cell Metabolism, vol. 24, no. 6, pp. 807-819. https://doi.org/10.1016/j.cmet.2016.10.008

@article{dd0e97a365e24f8b81081956a787f854,

title = "Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity",

keywords = "cholesterol metabolism, epigenetics, glutamine metabolism, glycolysis, trained immunity",

author = "Arts, \{Rob J.W.\} and Boris Novakovic and \{ter Horst\}, Rob and Agostinho Carvalho and Siroon Bekkering and Ekta Lachmandas and Fernando Rodrigues and Ricardo Silvestre and Cheng, \{Shih Chin\} and Wang, \{Shuang Yin\} and Ehsan Habibi and Gon{\c c}alves, \{Lu{\'i}s G.\} and In{\^e}s Mesquita and Cristina Cunha and \{van Laarhoven\}, Arjan and \{van de Veerdonk\}, \{Frank L.\} and Williams, \{David L.\} and \{van der Meer\}, \{Jos W.M.\} and Colin Logie and O'Neill, \{Luke A.\} and Dinarello, \{Charles A.\} and Riksen, \{Niels P.\} and \{van Crevel\}, Reinout and Clary Clish and Notebaart, \{Richard A.\} and Joosten, \{Leo A.B.\} and Stunnenberg, \{Hendrik G.\} and Xavier, \{Ramnik J.\} and Netea, \{Mihai G.\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = dec,

day = "13",

doi = "10.1016/j.cmet.2016.10.008",

language = "English",

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AU - Arts, Rob J.W.

AU - Novakovic, Boris

AU - ter Horst, Rob

AU - Carvalho, Agostinho

AU - Bekkering, Siroon

AU - Lachmandas, Ekta

AU - Rodrigues, Fernando

AU - Silvestre, Ricardo

AU - Cheng, Shih Chin

AU - Wang, Shuang Yin

AU - Habibi, Ehsan

AU - Gonçalves, Luís G.

AU - Mesquita, Inês

AU - Cunha, Cristina

AU - van Laarhoven, Arjan

AU - van de Veerdonk, Frank L.

AU - Williams, David L.

AU - van der Meer, Jos W.M.

AU - Logie, Colin

AU - O'Neill, Luke A.

AU - Dinarello, Charles A.

AU - Riksen, Niels P.

AU - van Crevel, Reinout

AU - Clish, Clary

AU - Notebaart, Richard A.

AU - Joosten, Leo A.B.

AU - Stunnenberg, Hendrik G.

AU - Xavier, Ramnik J.

AU - Netea, Mihai G.

PY - 2016/12/13

Y1 - 2016/12/13

KW - cholesterol metabolism

KW - epigenetics

KW - glutamine metabolism

KW - glycolysis

KW - trained immunity

UR - https://www.scopus.com/pages/publications/85003874481

UR - https://www.scopus.com/pages/publications/85003874481#tab=citedBy

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DO - 10.1016/j.cmet.2016.10.008

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AN - SCOPUS:85003874481

SN - 1550-4131

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JO - Cell Metabolism

JF - Cell Metabolism

IS - 6

ER -

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

ASJC Scopus Subject Areas

Keywords

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