Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes

Shuya Du; Xiaojin Zhang; Yunxiao Jia; Peipei Peng; Qiuyue Kong; Surong Jiang; Yuehua Li; Chuanfu Li; Zhengnian Ding; Li Liu

doi:10.7150/thno.82607

Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes

Shuya Du
, Xiaojin Zhang
, Yunxiao Jia
, Peipei Peng
, Qiuyue Kong
, Surong Jiang
, Yuehua Li
, Chuanfu Li
, Zhengnian Ding
, Li Liu

Department of Surgery

The First Affiliated Hospital of Nanjing Medical University
Nanjing Medical University

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3856-3871
Number of pages	16
Journal	Theranostics
Volume	13
Issue number	11
DOIs	https://doi.org/10.7150/thno.82607
State	Published - 2023

ASJC Scopus Subject Areas

Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Keywords

Chemotaxis
Heat shock protein A12A (HSPA12A)
Hepatocyte
High-mobility group box 1(HMGB1)
Lactylation
Liver ischemia/reperfusion (LI/R)
Macrophage

Access to Document

10.7150/thno.82607

Cite this

@article{dd14779fd56f4d09aa3587a53cbbc231,

title = "Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes",

keywords = "Chemotaxis, Heat shock protein A12A (HSPA12A), Hepatocyte, High-mobility group box 1(HMGB1), Lactylation, Liver ischemia/reperfusion (LI/R), Macrophage",

author = "Shuya Du and Xiaojin Zhang and Yunxiao Jia and Peipei Peng and Qiuyue Kong and Surong Jiang and Yuehua Li and Chuanfu Li and Zhengnian Ding and Li Liu",

year = "2023",

doi = "10.7150/thno.82607",

language = "English",

volume = "13",

pages = "3856--3871",

journal = "Theranostics",

issn = "1838-7640",

number = "11",

}

TY - JOUR

T1 - Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes

AU - Du, Shuya

AU - Zhang, Xiaojin

AU - Jia, Yunxiao

AU - Peng, Peipei

AU - Kong, Qiuyue

AU - Jiang, Surong

AU - Li, Yuehua

AU - Li, Chuanfu

AU - Ding, Zhengnian

AU - Liu, Li

PY - 2023

Y1 - 2023

KW - Chemotaxis

KW - Heat shock protein A12A (HSPA12A)

KW - Hepatocyte

KW - High-mobility group box 1(HMGB1)

KW - Lactylation

KW - Liver ischemia/reperfusion (LI/R)

KW - Macrophage

UR - https://www.scopus.com/pages/publications/85164845542

UR - https://www.scopus.com/pages/publications/85164845542#tab=citedBy

U2 - 10.7150/thno.82607

DO - 10.7150/thno.82607

M3 - Article

C2 - 37441587

AN - SCOPUS:85164845542

SN - 1838-7640

VL - 13

SP - 3856

EP - 3871

JO - Theranostics

JF - Theranostics

IS - 11

ER -

Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes

ASJC Scopus Subject Areas

Keywords

Access to Document

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