In Utero Exposure to Organochlorine Pesticides and Early Menarche in the Avon Longitudinal Study of Parents and Children

Gonza Namulanda; Mildred Maisonet; Ethel Taylor; W. Dana Flanders; David Olsen; Andreas Sjodin; Judith R. Qualters; John Vena; Kate Northstone; Luke Naeher

doi:10.1016/j.envint.2016.06.001

In Utero Exposure to Organochlorine Pesticides and Early Menarche in the Avon Longitudinal Study of Parents and Children

Gonza Namulanda, Mildred Maisonet, Ethel Taylor, W. Dana Flanders, David Olsen, Andreas Sjodin, Judith R. Qualters, John Vena, Kate Northstone, Luke Naeher

Department of Biostatistics and Epidemiology

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction

Epidemiologic data supporting the role of organochlorine pesticides in pubertal development are limited.

Methods

Using a nested case-control design, serum collected during pregnancy from mothers of 218 girls who reported menarche before 11.5 years of age (cases) and 230 girls who reported menarche at or after 11.5 years of age (controls) was analyzed for 9 organochlorines and metabolites. We analyzed the association between in utero organochlorine concentrations and early menarche using multivariate logistic regression controlling for mother's age at menarche, or mother's prenatal BMI.

Results

We did not observe an association between in utero exposure to HCB, β-HCH, ϒ-HCH, p,p′-DDT, p,p′-DDE, oxychlordane or trans-nonachlor and early menarche.

Conclusions

This study is the first to examine the association between in utero exposure to HCB, β-HCH, ϒ-HCH, oxychlordane or trans-nonachlor and early menarche. In utero exposure to organochlorine pesticides does not appear to have a role in the timing of menarche in this study.

Original language	American English
Journal	Environment International
Volume	94
DOIs	https://doi.org/10.1016/j.envint.2016.06.001
State	Published - Sep 1 2016

Keywords

ALSPAC
endocrine disrupting compounds
menarche girls
organochlorine pesticides
puberty

Disciplines

Endocrinology, Diabetes, and Metabolism
Environmental Public Health
Epidemiology

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https://doi.org/10.1016/j.envint.2016.06.001

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@article{5c15b8b825784e099d3548993d3ac1de,

title = "In Utero Exposure to Organochlorine Pesticides and Early Menarche in the Avon Longitudinal Study of Parents and Children",

abstract = " Introduction Epidemiologic data supporting the role of organochlorine pesticides in pubertal development are limited. Methods Using a nested case-control design, serum collected during pregnancy from mothers of 218 girls who reported menarche before 11.5 years of age (cases) and 230 girls who reported menarche at or after 11.5 years of age (controls) was analyzed for 9 organochlorines and metabolites. We analyzed the association between in utero organochlorine concentrations and early menarche using multivariate logistic regression controlling for mother's age at menarche, or mother's prenatal BMI. Results We did not observe an association between in utero exposure to HCB, β-HCH, ϒ-HCH, p,p′-DDT, p,p′-DDE, oxychlordane or trans-nonachlor and early menarche. Conclusions This study is the first to examine the association between in utero exposure to HCB, β-HCH, ϒ-HCH, oxychlordane or trans-nonachlor and early menarche. In utero exposure to organochlorine pesticides does not appear to have a role in the timing of menarche in this study.",

keywords = "ALSPAC, endocrine disrupting compounds, menarche girls, organochlorine pesticides, puberty",

author = "Gonza Namulanda and Mildred Maisonet and Ethel Taylor and Flanders, \{W. Dana\} and David Olsen and Andreas Sjodin and Qualters, \{Judith R.\} and John Vena and Kate Northstone and Luke Naeher",

year = "2016",

month = sep,

day = "1",

doi = "10.1016/j.envint.2016.06.001",

language = "American English",

volume = "94",

journal = "Environment International",

}

TY - JOUR

T1 - In Utero Exposure to Organochlorine Pesticides and Early Menarche in the Avon Longitudinal Study of Parents and Children

AU - Namulanda, Gonza

AU - Maisonet, Mildred

AU - Taylor, Ethel

AU - Flanders, W. Dana

AU - Olsen, David

AU - Sjodin, Andreas

AU - Qualters, Judith R.

AU - Vena, John

AU - Northstone, Kate

AU - Naeher, Luke

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Introduction Epidemiologic data supporting the role of organochlorine pesticides in pubertal development are limited. Methods Using a nested case-control design, serum collected during pregnancy from mothers of 218 girls who reported menarche before 11.5 years of age (cases) and 230 girls who reported menarche at or after 11.5 years of age (controls) was analyzed for 9 organochlorines and metabolites. We analyzed the association between in utero organochlorine concentrations and early menarche using multivariate logistic regression controlling for mother's age at menarche, or mother's prenatal BMI. Results We did not observe an association between in utero exposure to HCB, β-HCH, ϒ-HCH, p,p′-DDT, p,p′-DDE, oxychlordane or trans-nonachlor and early menarche. Conclusions This study is the first to examine the association between in utero exposure to HCB, β-HCH, ϒ-HCH, oxychlordane or trans-nonachlor and early menarche. In utero exposure to organochlorine pesticides does not appear to have a role in the timing of menarche in this study.

AB - Introduction Epidemiologic data supporting the role of organochlorine pesticides in pubertal development are limited. Methods Using a nested case-control design, serum collected during pregnancy from mothers of 218 girls who reported menarche before 11.5 years of age (cases) and 230 girls who reported menarche at or after 11.5 years of age (controls) was analyzed for 9 organochlorines and metabolites. We analyzed the association between in utero organochlorine concentrations and early menarche using multivariate logistic regression controlling for mother's age at menarche, or mother's prenatal BMI. Results We did not observe an association between in utero exposure to HCB, β-HCH, ϒ-HCH, p,p′-DDT, p,p′-DDE, oxychlordane or trans-nonachlor and early menarche. Conclusions This study is the first to examine the association between in utero exposure to HCB, β-HCH, ϒ-HCH, oxychlordane or trans-nonachlor and early menarche. In utero exposure to organochlorine pesticides does not appear to have a role in the timing of menarche in this study.

KW - ALSPAC

KW - endocrine disrupting compounds

KW - menarche girls

KW - organochlorine pesticides

KW - puberty

UR - https://dc.etsu.edu/etsu-works/30

UR - https://doi.org/10.1016/j.envint.2016.06.001

U2 - 10.1016/j.envint.2016.06.001

DO - 10.1016/j.envint.2016.06.001

M3 - Article

VL - 94

JO - Environment International

JF - Environment International

ER -

In Utero Exposure to Organochlorine Pesticides and Early Menarche in the Avon Longitudinal Study of Parents and Children

Abstract

Keywords

Disciplines

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