Mutation and Genome Evolution

L. Y. Yampolsky

doi:10.1016/B978-0-12-800049-6.00170-0

Mutation and Genome Evolution

L. Y. Yampolsky

Department of Biological Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Genome composition and architecture is shaped by two types of processes: those that introduce heritable changes (mutagenesis) and those that determine the fate of such changes in the populations (genetic drift and selection). Chemical and biological properties of mutagenesis determines the frequencies at which different type of mutations occur, which, in turn, determines their rates of fixation by drift and affects the spectrum of mutations available for selection to operate on. As the result, genomes of living organisms carry many signatures mutagenesis.

Original language	American English
Title of host publication	Encyclopedia of Evolutionary Biology
DOIs	https://doi.org/10.1016/B978-0-12-800049-6.00170-0
State	Published - Apr 14 2016

Keywords

copy number variation
CpG dinucleotides
deletions
DNA repair
DNA replication
ectopic crossing-over
gene conversion
genome
insertions
isochores
microsatellites
mutations
segmental duplications
selection
strand asymmetry
transitions
transposons

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10.1016/B978-0-12-800049-6.00170-0License: CC BY

https://doi.org/10.1016/B978-0-12-800049-6.00170-0

Cite this

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title = "Mutation and Genome Evolution",

abstract = " Genome composition and architecture is shaped by two types of processes: those that introduce heritable changes (mutagenesis) and those that determine the fate of such changes in the populations (genetic drift and selection). Chemical and biological properties of mutagenesis determines the frequencies at which different type of mutations occur, which, in turn, determines their rates of fixation by drift and affects the spectrum of mutations available for selection to operate on. As the result, genomes of living organisms carry many signatures mutagenesis.",

keywords = "copy number variation, CpG dinucleotides, deletions, DNA repair, DNA replication, ectopic crossing-over, gene conversion, genome, insertions, isochores, microsatellites, mutations, segmental duplications, selection, strand asymmetry, transitions, transposons",

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doi = "10.1016/B978-0-12-800049-6.00170-0",

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T1 - Mutation and Genome Evolution

AU - Yampolsky, L. Y.

PY - 2016/4/14

Y1 - 2016/4/14

N2 - Genome composition and architecture is shaped by two types of processes: those that introduce heritable changes (mutagenesis) and those that determine the fate of such changes in the populations (genetic drift and selection). Chemical and biological properties of mutagenesis determines the frequencies at which different type of mutations occur, which, in turn, determines their rates of fixation by drift and affects the spectrum of mutations available for selection to operate on. As the result, genomes of living organisms carry many signatures mutagenesis.

AB - Genome composition and architecture is shaped by two types of processes: those that introduce heritable changes (mutagenesis) and those that determine the fate of such changes in the populations (genetic drift and selection). Chemical and biological properties of mutagenesis determines the frequencies at which different type of mutations occur, which, in turn, determines their rates of fixation by drift and affects the spectrum of mutations available for selection to operate on. As the result, genomes of living organisms carry many signatures mutagenesis.

KW - copy number variation

KW - CpG dinucleotides

KW - deletions

KW - DNA repair

KW - DNA replication

KW - ectopic crossing-over

KW - gene conversion

KW - genome

KW - insertions

KW - isochores

KW - microsatellites

KW - mutations

KW - segmental duplications

KW - selection

KW - strand asymmetry

KW - transitions

KW - transposons

UR - https://dc.etsu.edu/etsu-works/15070

UR - https://doi.org/10.1016/B978-0-12-800049-6.00170-0

U2 - 10.1016/B978-0-12-800049-6.00170-0

DO - 10.1016/B978-0-12-800049-6.00170-0

M3 - Chapter

BT - Encyclopedia of Evolutionary Biology

ER -

Mutation and Genome Evolution

Abstract

Keywords

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