Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival

Shota Torigoe; Sumayah Salie; Roanne Keeton; Beren Aylan; Ben J. Appelmelk; David L. Williams; Douglas W. Lowman; Toshihiko Sugiki; Sohkichi Matsumoto; Akira Kawano; Satoru Mizuno; Kazuhiro Matsuo; Jonas N. Søndergaard; James B. Wing; Maxine A. Höft; Romey Shoesmith; Mthawelanga Ndengane; Anna K. Coussens; Janet A. Willment; Maximiliano G. Gutierrez; Jennifer Claire Hoving; Sho Yamasaki; Gordon D. Brown

doi:10.1126/sciimmunol.adw0732

Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival

Shota Torigoe
, Sumayah Salie
, Roanne Keeton
, Beren Aylan
, Ben J. Appelmelk
, David L. Williams
, Douglas W. Lowman
, Toshihiko Sugiki
, Sohkichi Matsumoto
, Akira Kawano
, Satoru Mizuno
, Kazuhiro Matsuo
, Jonas N. Søndergaard
, James B. Wing
, Maxine A. Höft
, Romey Shoesmith
, Mthawelanga Ndengane
, Anna K. Coussens
, Janet A. Willment
, Maximiliano G. Gutierrez

Jennifer Claire Hoving, Sho Yamasaki, Gordon D. Brown

Department of Surgery

Osaka University
National Institute of Infectious Diseases
University of Cape Town
Francis Crick Institute
Amsterdam University Medical Centers
Quillen College of Medicine
Niigata University, Graduate School of Medical and Dental Science
Mie University Graduate School of Medicine
Hokkaido University
University of Exeter
Walter and Eliza Hall Institute of Medical Research
Research Institute for Microbial Diseases
Chiba University
Kyushu University

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	eadw0732
Journal	Science Immunology
Volume	11
Issue number	115
DOIs	https://doi.org/10.1126/sciimmunol.adw0732
State	Published - Jan 2026

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

Access to Document

10.1126/sciimmunol.adw0732

Cite this

Torigoe, S., Salie, S., Keeton, R., Aylan, B., Appelmelk, B. J., Williams, D. L., Lowman, D. W., Sugiki, T., Matsumoto, S., Kawano, A., Mizuno, S., Matsuo, K., Søndergaard, J. N., Wing, J. B., Höft, M. A., Shoesmith, R., Ndengane, M., Coussens, A. K., Willment, J. A., ... Brown, G. D. (2026). Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival. Science Immunology, 11(115), Article eadw0732. https://doi.org/10.1126/sciimmunol.adw0732

Torigoe, S, Salie, S, Keeton, R, Aylan, B, Appelmelk, BJ, Williams, DL, Lowman, DW, Sugiki, T, Matsumoto, S, Kawano, A, Mizuno, S, Matsuo, K, Søndergaard, JN, Wing, JB, Höft, MA, Shoesmith, R, Ndengane, M, Coussens, AK, Willment, JA, Gutierrez, MG, Hoving, JC, Yamasaki, S & Brown, GD 2026, 'Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival', Science Immunology, vol. 11, no. 115, eadw0732. https://doi.org/10.1126/sciimmunol.adw0732

@article{26ff1e16370346d89903644e977a81a9,

title = "Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival",

author = "Shota Torigoe and Sumayah Salie and Roanne Keeton and Beren Aylan and Appelmelk, \{Ben J.\} and Williams, \{David L.\} and Lowman, \{Douglas W.\} and Toshihiko Sugiki and Sohkichi Matsumoto and Akira Kawano and Satoru Mizuno and Kazuhiro Matsuo and S{\o}ndergaard, \{Jonas N.\} and Wing, \{James B.\} and H{\"o}ft, \{Maxine A.\} and Romey Shoesmith and Mthawelanga Ndengane and Coussens, \{Anna K.\} and Willment, \{Janet A.\} and Gutierrez, \{Maximiliano G.\} and Hoving, \{Jennifer Claire\} and Sho Yamasaki and Brown, \{Gordon D.\}",

note = "Publisher Copyright: {\textcopyright} 2026 The Authors, some rights reserved;.",

year = "2026",

month = jan,

doi = "10.1126/sciimmunol.adw0732",

language = "English",

volume = "11",

journal = "Science Immunology",

issn = "2470-9468",

number = "115",

}

TY - JOUR

T1 - Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival

AU - Torigoe, Shota

AU - Salie, Sumayah

AU - Keeton, Roanne

AU - Aylan, Beren

AU - Appelmelk, Ben J.

AU - Williams, David L.

AU - Lowman, Douglas W.

AU - Sugiki, Toshihiko

AU - Matsumoto, Sohkichi

AU - Kawano, Akira

AU - Mizuno, Satoru

AU - Matsuo, Kazuhiro

AU - Søndergaard, Jonas N.

AU - Wing, James B.

AU - Höft, Maxine A.

AU - Shoesmith, Romey

AU - Ndengane, Mthawelanga

AU - Coussens, Anna K.

AU - Willment, Janet A.

AU - Gutierrez, Maximiliano G.

AU - Hoving, Jennifer Claire

AU - Yamasaki, Sho

AU - Brown, Gordon D.

PY - 2026/1

Y1 - 2026/1

UR - https://www.scopus.com/pages/publications/105027075516

UR - https://www.scopus.com/pages/publications/105027075516#tab=citedBy

U2 - 10.1126/sciimmunol.adw0732

DO - 10.1126/sciimmunol.adw0732

M3 - Article

C2 - 41512079

AN - SCOPUS:105027075516

SN - 2470-9468

VL - 11

JO - Science Immunology

JF - Science Immunology

IS - 115

M1 - eadw0732

ER -

Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival

ASJC Scopus Subject Areas

Access to Document

Other files and links

Cite this