Osteopontin: A Novel Inflammatory Mediator of Cardiovascular Disease

Mahipal Singh; Srinivas Ananthula; Denise M. Milhorn; Guha Krishnaswamy; Krishna Singh

doi:10.2741/2059

Osteopontin: A Novel Inflammatory Mediator of Cardiovascular Disease

Mahipal Singh
, Srinivas Ananthula
, Denise M. Milhorn
, Guha Krishnaswamy
, Krishna Singh

Department of Biomedical Sciences

East Tennessee State University

Research output: Contribution to journal › Article › peer-review

Abstract

Osteopontin, also called cytokine Eta-1, is a multifunctional protein containing Arg-Gly-Asp-Ser (RODS) cell-binding sequence. It interacts with αvβ1, αvβ3 and αvβ5 integrins and CD44 receptors. OPN is suggested to play a role during inflammation via the recruitment and retention of macrophages and T-cells to inflamed sites. OPN regulates the production of inflammatory cytokines and nitric oxide in macrophages. In this review, we will discuss diverse roles of OPN related to cardiovascular diseases, including atherosclerosis, valvular stenosis, hypertrophy, myocardial infarction and heart failure.

Original language	American English
Journal	Frontiers in Bioscience
Volume	12
DOIs	https://doi.org/10.2741/2059
State	Published - Jun 7 2007

Keywords

coronary artery disease
left ventricular hypertrophy
myocardial infarction
myocardial remodeling
osteopontin
valvular calcification
vascular inflammation

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title = "Osteopontin: A Novel Inflammatory Mediator of Cardiovascular Disease",

abstract = " Osteopontin, also called cytokine Eta-1, is a multifunctional protein containing Arg-Gly-Asp-Ser (RODS) cell-binding sequence. It interacts with αvβ1, αvβ3 and αvβ5 integrins and CD44 receptors. OPN is suggested to play a role during inflammation via the recruitment and retention of macrophages and T-cells to inflamed sites. OPN regulates the production of inflammatory cytokines and nitric oxide in macrophages. In this review, we will discuss diverse roles of OPN related to cardiovascular diseases, including atherosclerosis, valvular stenosis, hypertrophy, myocardial infarction and heart failure.",

keywords = "coronary artery disease, left ventricular hypertrophy, myocardial infarction, myocardial remodeling, osteopontin, valvular calcification, vascular inflammation",

author = "Mahipal Singh and Srinivas Ananthula and Milhorn, \{Denise M.\} and Guha Krishnaswamy and Krishna Singh",

year = "2007",

month = jun,

day = "7",

doi = "10.2741/2059",

language = "American English",

volume = "12",

journal = "Frontiers in Bioscience",

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T1 - Osteopontin: A Novel Inflammatory Mediator of Cardiovascular Disease

AU - Singh, Mahipal

AU - Ananthula, Srinivas

AU - Milhorn, Denise M.

AU - Krishnaswamy, Guha

AU - Singh, Krishna

PY - 2007/6/7

Y1 - 2007/6/7

N2 - Osteopontin, also called cytokine Eta-1, is a multifunctional protein containing Arg-Gly-Asp-Ser (RODS) cell-binding sequence. It interacts with αvβ1, αvβ3 and αvβ5 integrins and CD44 receptors. OPN is suggested to play a role during inflammation via the recruitment and retention of macrophages and T-cells to inflamed sites. OPN regulates the production of inflammatory cytokines and nitric oxide in macrophages. In this review, we will discuss diverse roles of OPN related to cardiovascular diseases, including atherosclerosis, valvular stenosis, hypertrophy, myocardial infarction and heart failure.

AB - Osteopontin, also called cytokine Eta-1, is a multifunctional protein containing Arg-Gly-Asp-Ser (RODS) cell-binding sequence. It interacts with αvβ1, αvβ3 and αvβ5 integrins and CD44 receptors. OPN is suggested to play a role during inflammation via the recruitment and retention of macrophages and T-cells to inflamed sites. OPN regulates the production of inflammatory cytokines and nitric oxide in macrophages. In this review, we will discuss diverse roles of OPN related to cardiovascular diseases, including atherosclerosis, valvular stenosis, hypertrophy, myocardial infarction and heart failure.

KW - coronary artery disease

KW - left ventricular hypertrophy

KW - myocardial infarction

KW - myocardial remodeling

KW - osteopontin

KW - valvular calcification

KW - vascular inflammation

UR - https://dc.etsu.edu/etsu-works/17809

UR - https://doi.org/10.2741/2059

U2 - 10.2741/2059

DO - 10.2741/2059

M3 - Article

VL - 12

JO - Frontiers in Bioscience

JF - Frontiers in Bioscience

ER -

Osteopontin: A Novel Inflammatory Mediator of Cardiovascular Disease

Abstract

Keywords

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