Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box

Hong Huang; Andrew P. Degnan; Anand Balakrishnan; Amy Easton; Michael Gulianello; Yanling Huang; Michele Matchett; Gail Mattson; Regina Miller; Kenneth S. Santone; Arun Senapati; Eric E. Shields; Digavalli V. Sivarao; Lawrence B. Snyder; Ryan Westphal; Valerie J. Whiterock; Fukang Yang; Joanne J. Bronson; John E. Macor

doi:10.1016/j.bmcl.2016.07.065

Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box

Hong Huang
, Andrew P. Degnan
, Anand Balakrishnan
, Amy Easton
, Michael Gulianello
, Yanling Huang
, Michele Matchett
, Gail Mattson
, Regina Miller
, Kenneth S. Santone
, Arun Senapati
, Eric E. Shields
, Digavalli V. Sivarao
, Lawrence B. Snyder
, Ryan Westphal
, Valerie J. Whiterock
, Fukang Yang
, Joanne J. Bronson
, John E. Macor

Department of Pharmaceutical Sciences

Bristol-Myers Squibb

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	4165-4169
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	17
DOIs	https://doi.org/10.1016/j.bmcl.2016.07.065
State	Published - 2016

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Keywords

Cognition
mGlu5
mGluR5
Positive allosteric modulator
Schizophrenia
Silent allosteric modulator

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10.1016/j.bmcl.2016.07.065

Cite this

Huang, H., Degnan, A. P., Balakrishnan, A., Easton, A., Gulianello, M., Huang, Y., Matchett, M., Mattson, G., Miller, R., Santone, K. S., Senapati, A., Shields, E. E., Sivarao, D. V., Snyder, L. B., Westphal, R., Whiterock, V. J., Yang, F., Bronson, J. J., & Macor, J. E. (2016). Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box. Bioorganic and Medicinal Chemistry Letters, 26(17), 4165-4169. https://doi.org/10.1016/j.bmcl.2016.07.065

Huang, H, Degnan, AP, Balakrishnan, A, Easton, A, Gulianello, M, Huang, Y, Matchett, M, Mattson, G, Miller, R, Santone, KS, Senapati, A, Shields, EE, Sivarao, DV, Snyder, LB, Westphal, R, Whiterock, VJ, Yang, F, Bronson, JJ & Macor, JE 2016, 'Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box', Bioorganic and Medicinal Chemistry Letters, vol. 26, no. 17, pp. 4165-4169. https://doi.org/10.1016/j.bmcl.2016.07.065

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title = "Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box",

keywords = "Cognition, mGlu5, mGluR5, Positive allosteric modulator, Schizophrenia, Silent allosteric modulator",

author = "Hong Huang and Degnan, \{Andrew P.\} and Anand Balakrishnan and Amy Easton and Michael Gulianello and Yanling Huang and Michele Matchett and Gail Mattson and Regina Miller and Santone, \{Kenneth S.\} and Arun Senapati and Shields, \{Eric E.\} and Sivarao, \{Digavalli V.\} and Snyder, \{Lawrence B.\} and Ryan Westphal and Whiterock, \{Valerie J.\} and Fukang Yang and Bronson, \{Joanne J.\} and Macor, \{John E.\}",

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year = "2016",

doi = "10.1016/j.bmcl.2016.07.065",

language = "English",

volume = "26",

pages = "4165--4169",

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T1 - Oxazolidinone-based allosteric modulators of mGluR5

T2 - Defining molecular switches to create a pharmacological tool box

AU - Huang, Hong

AU - Degnan, Andrew P.

AU - Balakrishnan, Anand

AU - Easton, Amy

AU - Gulianello, Michael

AU - Huang, Yanling

AU - Matchett, Michele

AU - Mattson, Gail

AU - Miller, Regina

AU - Santone, Kenneth S.

AU - Senapati, Arun

AU - Shields, Eric E.

AU - Sivarao, Digavalli V.

AU - Snyder, Lawrence B.

AU - Westphal, Ryan

AU - Whiterock, Valerie J.

AU - Yang, Fukang

AU - Bronson, Joanne J.

AU - Macor, John E.

PY - 2016

Y1 - 2016

KW - Cognition

KW - mGlu5

KW - mGluR5

KW - Positive allosteric modulator

KW - Schizophrenia

KW - Silent allosteric modulator

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UR - https://www.scopus.com/pages/publications/84981287053#tab=citedBy

U2 - 10.1016/j.bmcl.2016.07.065

DO - 10.1016/j.bmcl.2016.07.065

M3 - Article

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AN - SCOPUS:84981287053

SN - 0960-894X

VL - 26

SP - 4165

EP - 4169

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 17

ER -

Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box

ASJC Scopus Subject Areas

Keywords

Access to Document

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