The Toxicology of Chemical Interactions During Pregnancy in the Mouse: Caffeine and Phenytoin

R. G. Skalko; P. D. Poche; Thomas E. Kwasigroch

doi:10.1016/0300-483X(84)90057-X

The Toxicology of Chemical Interactions During Pregnancy in the Mouse: Caffeine and Phenytoin

R. G. Skalko, P. D. Poche, Thomas E. Kwasigroch

Quillen-Dishner College of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation. Caffeine, over a range of dosages, showed limited embryotoxic activity. Phenytoin was also weakly teratogenic and dosages needed to elicit embryotoxicity were accompanied by a significant increase in maternal lethality. Pretreatment with caffeine enhanced phenytoin-induced toxicity and teratogenicity and these observations confirm that caffeine has the ability to function as a coteratogen. Pretreatment with phenytoin produced a significant increase in maternal lethality following caffeine administration but no co-teratogenic effect. It is suggested that these results are the consequence of a yet undefined interaction at critical receptor sites in the maternal-embryo unit.

Original language	American English
Journal	Toxicology
Volume	30
DOIs	https://doi.org/10.1016/0300-483X(84)90057-X
State	Published - Feb 14 1984

Keywords

Caffeine
Cleft palate
Coteratogen
Maternal lethality
Phenytoin

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title = "The Toxicology of Chemical Interactions During Pregnancy in the Mouse: Caffeine and Phenytoin",

abstract = " The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation. Caffeine, over a range of dosages, showed limited embryotoxic activity. Phenytoin was also weakly teratogenic and dosages needed to elicit embryotoxicity were accompanied by a significant increase in maternal lethality. Pretreatment with caffeine enhanced phenytoin-induced toxicity and teratogenicity and these observations confirm that caffeine has the ability to function as a coteratogen. Pretreatment with phenytoin produced a significant increase in maternal lethality following caffeine administration but no co-teratogenic effect. It is suggested that these results are the consequence of a yet undefined interaction at critical receptor sites in the maternal-embryo unit.",

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AU - Skalko, R. G.

AU - Poche, P. D.

AU - Kwasigroch, Thomas E.

PY - 1984/2/14

Y1 - 1984/2/14

N2 - The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation. Caffeine, over a range of dosages, showed limited embryotoxic activity. Phenytoin was also weakly teratogenic and dosages needed to elicit embryotoxicity were accompanied by a significant increase in maternal lethality. Pretreatment with caffeine enhanced phenytoin-induced toxicity and teratogenicity and these observations confirm that caffeine has the ability to function as a coteratogen. Pretreatment with phenytoin produced a significant increase in maternal lethality following caffeine administration but no co-teratogenic effect. It is suggested that these results are the consequence of a yet undefined interaction at critical receptor sites in the maternal-embryo unit.

AB - The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation. Caffeine, over a range of dosages, showed limited embryotoxic activity. Phenytoin was also weakly teratogenic and dosages needed to elicit embryotoxicity were accompanied by a significant increase in maternal lethality. Pretreatment with caffeine enhanced phenytoin-induced toxicity and teratogenicity and these observations confirm that caffeine has the ability to function as a coteratogen. Pretreatment with phenytoin produced a significant increase in maternal lethality following caffeine administration but no co-teratogenic effect. It is suggested that these results are the consequence of a yet undefined interaction at critical receptor sites in the maternal-embryo unit.

KW - Caffeine

KW - Cleft palate

KW - Coteratogen

KW - Maternal lethality

KW - Phenytoin

UR - https://dc.etsu.edu/etsu-works/13036

UR - https://doi.org/10.1016/0300-483X(84)90057-X

U2 - 10.1016/0300-483X(84)90057-X

DO - 10.1016/0300-483X(84)90057-X

M3 - Article

VL - 30

JO - Toxicology

JF - Toxicology

ER -

The Toxicology of Chemical Interactions During Pregnancy in the Mouse: Caffeine and Phenytoin

Abstract

Keywords

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