TRF2 inhibition rather than telomerase disruption drives CD4T cell dysfunction during chronic viral infection

Lam Ngoc Thao Nguyen; Lam Nhat Nguyen; Juan Zhao; Madison Schank; Xindi Dang; Dechao Cao; Sushant Khanal; Xiao Y. Wu; Yi Zhang; Jinyu Zhang; Shunbin Ning; Ling Wang; Mohamed El Gazzar; Jonathan P. Moorman; Zhi Q. Yao

doi:10.1242/jcs.259481

TRF2 inhibition rather than telomerase disruption drives CD4T cell dysfunction during chronic viral infection

Lam Ngoc Thao Nguyen
, Lam Nhat Nguyen
, Juan Zhao
, Madison Schank
, Xindi Dang
, Dechao Cao
, Sushant Khanal
, Xiao Y. Wu
, Yi Zhang
, Jinyu Zhang
, Shunbin Ning
, Ling Wang
, Mohamed El Gazzar
, Jonathan P. Moorman
, Zhi Q. Yao

Department of Internal Medicine

Quillen College of Medicine

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	135
Journal	Journal of Cell Science
Volume	135
Issue number	13
DOIs	https://doi.org/10.1242/jcs.259481
State	Published - Jul 2022

ASJC Scopus Subject Areas

Cell Biology

Keywords

HCV
HIV
T-cell dysfunction
Telomerase
Telomere erosion
TRF2

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10.1242/jcs.259481

Cite this

Nguyen, L. N. T., Nguyen, L. N., Zhao, J., Schank, M., Dang, X., Cao, D., Khanal, S., Wu, X. Y., Zhang, Y., Zhang, J., Ning, S., Wang, L., Gazzar, M. E., Moorman, J. P., & Yao, Z. Q. (2022). TRF2 inhibition rather than telomerase disruption drives CD4T cell dysfunction during chronic viral infection. Journal of Cell Science, 135(13), Article 135. https://doi.org/10.1242/jcs.259481

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title = "TRF2 inhibition rather than telomerase disruption drives CD4T cell dysfunction during chronic viral infection",

keywords = "HCV, HIV, T-cell dysfunction, Telomerase, Telomere erosion, TRF2",

author = "Nguyen, \{Lam Ngoc Thao\} and Nguyen, \{Lam Nhat\} and Juan Zhao and Madison Schank and Xindi Dang and Dechao Cao and Sushant Khanal and Wu, \{Xiao Y.\} and Yi Zhang and Jinyu Zhang and Shunbin Ning and Ling Wang and Gazzar, \{Mohamed El\} and Moorman, \{Jonathan P.\} and Yao, \{Zhi Q.\}",

year = "2022",

month = jul,

doi = "10.1242/jcs.259481",

language = "English",

volume = "135",

journal = "Journal of Cell Science",

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T1 - TRF2 inhibition rather than telomerase disruption drives CD4T cell dysfunction during chronic viral infection

AU - Nguyen, Lam Ngoc Thao

AU - Nguyen, Lam Nhat

AU - Zhao, Juan

AU - Schank, Madison

AU - Dang, Xindi

AU - Cao, Dechao

AU - Khanal, Sushant

AU - Wu, Xiao Y.

AU - Zhang, Yi

AU - Zhang, Jinyu

AU - Ning, Shunbin

AU - Wang, Ling

AU - Gazzar, Mohamed El

AU - Moorman, Jonathan P.

AU - Yao, Zhi Q.

PY - 2022/7

Y1 - 2022/7

KW - HCV

KW - HIV

KW - T-cell dysfunction

KW - Telomerase

KW - Telomere erosion

KW - TRF2

UR - https://www.scopus.com/pages/publications/85134083765

UR - https://www.scopus.com/pages/publications/85134083765#tab=citedBy

U2 - 10.1242/jcs.259481

DO - 10.1242/jcs.259481

M3 - Article

C2 - 35660868

AN - SCOPUS:85134083765

SN - 0021-9533

VL - 135

JO - Journal of Cell Science

JF - Journal of Cell Science

IS - 13

M1 - 135

ER -

TRF2 inhibition rather than telomerase disruption drives CD4T cell dysfunction during chronic viral infection

ASJC Scopus Subject Areas

Keywords

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